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目的 :在应用雷尼替丁加甲硝唑 (对照组 )的基础上加用醋氨己酸锌 (治疗组 )治疗有幽门螺杆菌 (Hp)感染的慢性胃炎和消化性溃疡患者 10 4例 ,观察醋氨己酸锌对 Hp阳性的胃炎和消化性溃疡患者的治疗效果。方法 :对照组给予雷尼替丁15 0 m g,bid,甲硝唑 2 0 0 m g,qid;治疗组在对照组的基础上加用醋氨己酸锌 30 0 m g,tid,共 4wk。结果 :治疗组的 Hp清除率明显高于对照组 (P<0 .0 5 ) ;消化性溃疡的愈合率虽高于对照组 ,但统计学上差异无显著性 (P>0 .0 5 )。结论 :醋氨己酸锌、雷尼替丁、甲硝唑三联疗法治疗 Hp阳性的慢性胃炎和消化性溃疡其 Hp的清除率明显高于对照组。
OBJECTIVE: To treat 104 cases of chronic gastritis and peptic ulcer patients with Helicobacter pylori (Hp) infection by adding zinc acetohexamide (treatment group) to ranitidine plus metronidazole (control group) , Observe the effect of zinc acetimide on Hp-positive gastritis and peptic ulcer patients. Methods: The control group was given ranitidine 15 0 m g bid and metronidazole 200 m g qid. The treatment group was given zinc acetate-aminocaproate 30 0 m g, tid for 4 weeks on the basis of the control group. Results: The Hp clearance rate of the treatment group was significantly higher than that of the control group (P <0.05). Although the healing rate of peptic ulcer was higher than that of the control group, there was no significant difference (P> 0.05) . CONCLUSION: The clearance rate of Hp in chronic gastritis and peptic ulcer patients with Hp positive chronic hepatitis and ranitidine plus metronidazole triple therapy is significantly higher than that of the control group.