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青霉素类药物作用迅速强大,疗效可靠,是临床最常用的一类抗生素,其配伍中的某些理化变化,已有很多报道。但配伍它药后的相互作用及应用中的一些问题,值得进一步研究,现就个人的几点体会报告如下,以引起临床重视。一、配伍问题(一)和四环素类伍用:青霉素类抗菌机理是阻碍细菌细胞壁合成,阻止细菌的发育,对繁殖期生长旺盛的细菌呈现强大的杀灭作用。而四环素类仅对静止状态下的细菌有抑制作用,故前者对后者抑制的静止状态下的细菌作用弱或无,故两者不主张联用。(二)和氨基甙类伍用:细菌在氨基甙的作用下合成无功能蛋白,且其合成并不停
Rapid and powerful penicillin drugs, efficacy and reliable, is the most commonly used clinical class of antibiotics, the compatibility of some of the physical and chemical changes, there have been many reports. However, after compatibility with its drug interactions and some of the problems in the application, it is worth further study, is now on the personal experience of the report as follows to attract clinical attention. First, the compatibility issues (A) and tetracycline class with: penicillin antibacterial mechanism is to hinder bacterial cell wall synthesis, to prevent the development of bacteria, reproductive growth of strong bacteria showed a strong killing effect. The tetracyclines only restrain bacteria in resting state, so the former inhibit the rest of the bacteria in the stationary state of weak or no effect, so the two do not advocate the combination. (B) and aminoglycosides Wu group: bacteria in the role of aminoglycoside synthesis of non-functional protein, and its synthesis does not stop