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氨基糖苷类药物(aminoglycosides)是一类能不可逆地破坏核糖体,从而阻止细菌的蛋白合成的杀菌性抗生素,它常用于治疗包括许多革兰氏阴性肠菌和葡萄球菌在内的眼和眼附属器的感染。硫酸庆大霉素和妥布霉素均为包括假单胞菌属在内的广谱抗生素,因此是对拟为革兰氏阴性细菌性角膜炎治疗的首选药物。为了预防和治疗轻度的外眼感染,常用0.3%的制剂,但对角膜感染,则需更高的浓度(1.5%)。然而,氨基糖苷类药物局部应用,对角膜和结膜上皮均可引起毒性反应。角膜的毒性反应表现为浅层点状角膜炎,角膜上皮再生延缓和角膜溃疡。结膜的毒性反应表现
Aminoglycosides, a class of bactericidal antibiotics that irreversibly disrupt ribosomes and thus prevent bacterial protein synthesis, are commonly used in the treatment of ocular and ocular ancestries, including many Gram-negative enterococci and staphylococci Infection. Gentamicin sulfate and tobramycin are broad-spectrum antibiotics, including Pseudomonas, and are therefore the drug of choice for the treatment of Gram-negative bacterial keratitis. For the prevention and treatment of mild external eye infections, 0.3% of the formulation is commonly used but for corneal infections a higher concentration (1.5%) is required. However, topical application of aminoglycosides can cause toxic reactions to the cornea and conjunctival epithelium. Corneal toxicity showed shallow punctate keratitis, delayed corneal epithelial regeneration and corneal ulcer. Conjunctival toxic reaction performance