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目的研究清肝化瘀胶囊对大鼠免疫性肝纤维化的防治作用。方法 Wistar大鼠随机分为7组,除对照组外,其余大鼠用牛血清白蛋白诱导免疫性肝纤维化模型,造模大鼠随机分为模型组,清肝化瘀胶囊低、中、高剂量(0.9、1.8、3.6 g/kg)组,复方鳖甲软肝片(2 g/kg)和秋水仙碱(0.25 mg/kg)阳性对照组。观察清肝化瘀胶囊对免疫性肝纤维化大鼠血清肝功能指标丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、总蛋白(TP)、白蛋白(ALB),以及肝羟脯氨酸(Hyp)、唾液酸(SA)的影响,计算肝脏、脾脏的脏器指数,观察肝组织病理学改变。结果清肝化瘀胶囊明显减小肝脏、脾脏的脏器指数,明显降低肝脏Hyp的水平,明显减轻肝纤维化程度,其作用随剂量增加而增强。结论清肝化瘀胶囊对大鼠免疫性肝纤维化有明显的防治作用。
Objective To study the preventive and therapeutic effects of Qinggan Huayu capsule on immune hepatic fibrosis in rats. Methods Wistar rats were randomly divided into 7 groups. Except for the control group, other rats were induced with bovine serum albumin to induce immune hepatic fibrosis. The model rats were randomly divided into model group, Qinggan Huayu capsule low, High dose (0.9,1.8,3.6 g / kg) group, Fufang Biejia Ruangan Pian (2 g / kg) and colchicine (0.25 mg / kg) positive control group. To observe the effect of Qinggan Huayu capsule on serum liver function indexes ALT, AST, ALB and albumin in rats with autoimmune liver fibrosis Proline (Hyp), sialic acid (SA), calculate the index of liver and spleen, and observe the pathological changes of liver tissue. Results Qinggan Huayu Capsule significantly reduced the organ index of liver and spleen, significantly reduced the level of liver Hyp, significantly reduced the degree of liver fibrosis, and its effect increased with dose. Conclusion Qinggan Huayu capsule has obvious preventive and therapeutic effects on immune hepatic fibrosis in rats.