【摘 要】
：
Cardiac dysfunction,a common consequence of sepsis,is the major contribution to morbidity and mortality in patients.Sodium tanshinone ⅡA sulfonate (STS) is a water-soluble derivative of Tanshinone ⅡA (TA),a main active component of Salvia miltiorrhiza Bun
【机 构】
：
College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, Ch
论文部分内容阅读
Cardiac dysfunction,a common consequence of sepsis,is the major contribution to morbidity and mortality in patients.Sodium tanshinone ⅡA sulfonate (STS) is a water-soluble derivative of Tanshinone ⅡA (TA),a main active component of Salvia miltiorrhiza Bunge,which has been widely used in China for the treatment of cardiovascular and cerebral system diseases.In the present study,the effect of STS on sepsis-induced cardiac dysfunction was investigated and its effect on survival rate of rats with sepsis was also evaluated.STS treatment could significantly decrease the serum levels of C-reactive protein (CRP),procalcitonin (PCT),cardiac troponin Ⅰ (cTn-Ⅰ),cardiac troponin T (cTn-T),and brain natriuretic peptide (BNP) in cecal ligation and puncture (CLP)-induced) septic rats and improve left ventricular function,particularly at 48 and 72 h after CLP.As the pathogenesis of septic myocardial dysfunction is attributable to dysregulated systemic inflammatory responses,several key cytokines,including tumor necrosis factor-α (TNF-α),interleukin-1β (IL-1β),interleukin-6 (IL-6),interleukin-10 (IL-10) and high mobility group protein B1 (HMGB 1),were detected to reveal the possible mechanism of attenuation of septic myocardial dysfunction after being treated by STS.Our study showed that STS,especially at a high dose (15 mg·kg-1),could efficiently suppress inflammatory responses in myocardium and reduce myocardial necrosis through markedly reducing production of myocardial TNF-α,IL-6 and HMGB1.STS significantly improved the 18-day survival rate of rats with sepsis from 0％ to 30％ (P ＜ 0.05).Therefore,STS could suppress inflammatory responses and improve left ventricular function in rats with sepsis,suggesting that it may be developed for the treatment of sepsis.
其他文献
Resistance to cisplatin (DDP)-based chemotherapy is a major cause of treatment failure in human gastric cancer (GC).It is necessary to identify the drugs to re-sensitize GC cells to DDP.In our previous research,Zuo Jin Wan Formula (ZJW) has been proved co
Due to ineffectiveness and side effects of existing analgesics, chronic pain has become one of the most complex and difficult problems in the clinic.Monoacylglycerol lipase (MAGL) is an essential hydrolase in the endocannabinoid system and has been identi
One new dimeric (1) and two monomeric sesquiterpene lactones (5 and 13),together with 10 known compounds (2-4,6-12),were isolated from Artemisia heptapotamica collected in Almaty region of Kazakhstan.All compounds were isolated from this plant for the fir
Two previously undescribed steroidal compounds,16,23-epoxy-22,26-epimino-cholest-22(N),23,25(26)-trien-3β-ol-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl-(1 →4)-β-D-galactopyranoside (1) and 26-O-β-D-glucopyranosyl-(25R)-5a-furost-20(22)-en-3β,26-diol
Poria cocos (Schw.) Wolf,an important medicinal and food fungus,is well known in East Asia.Due to growing market demand,long cultivation period,and consumption of pine trunk during cultivation,developing alternative methods for producing P.cocos and/or it
In the present study, four new sesquiterpenoids, chimonols A–D (compounds 1–4), together with four known compounds (5–8) were isolated from the EtOAc extract of Chimonanthus praecox Link. The structures of these new compounds were elucidated on the basis
Salvianolic acid A (SAA) is a water-soluble component from the root of Salvia Miltiorrhiza Bge,a traditional Chinese medicine,which has been used for the treatment of cerebrovascular diseases for centuries.The present study aimed to determine the brain pr
Poliumoside is representative of phenylethanoid glycosides,which are widely found in many plants.Poliumoside is also regarded as the main active component of Callicarpa kwangtungensis Chun (CK),though its oral bioavailability in mt is extremely low (0.69％
Nocathiacin Ⅰ,a glycosylated thiopeptide antibiotic,displays excellent antibacterial activities against multidrug resistant bacterial pathogens.Previously,a novel nocathiacin Ⅰ formulation for intravenous administration has been successfully developed and
Shenshao Tablet (SST),prepared from Paeoniae Radix Alba (PRA) and total ginsenoside of Ginseng Stems and Leaves (GSL),is a traditional Chinese medicine (TCM) preparation prescribed to treat coronary heart disease.However,its chemical composition and the c