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1979年10月,美国化工毒理研究所(CIIT)首先报道了甲醛的致癌性。该研究给F-344大鼠和B_6C_3F_1小鼠分别接触浓度为15、6、2ppm的甲醛蒸气,每个剂量组雌、雄动物各120只,每天染毒6小时,每周5天。结果,16个月后,15ppm组有3只大鼠发生鼻甲骨上皮鳞状细胞癌;18个月后,该剂量组罹患同样癌肿的大鼠数急剧增至36
October 1979, the United States Institute of Chemical Toxicology (CIIT) first reported the carcinogenicity of formaldehyde. In this study, F-344 rats and B_6C_3F_1 mice were respectively exposed to formaldehyde vapor at a concentration of 15,6,2ppm. Each dose group of 120 female and male animals were exposed to 6 hours a day for 5 days a week. After 16 months, three rats in the 15 ppm group developed turbinate epithelial squamous cell carcinoma; after 18 months, the number of rats with the same cancer in this dose group rose sharply to 36