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目的 评价复方联苯苄唑乳膏治疗体股癣的临床疗效及安全性。方法 采用随机双盲、有效对照、平行分组试验 ,与 1%联苯苄唑霜作对照比较。结果 观察了可供疗效评价的体股癣病例 67例 ,其中试验组 3 4例 ,对照组 3 3例。试验组治愈率 79.41% ,对照组为 72 .73 % ,两组有效率分别为 85 .2 9%和 81.82 % ,真菌清除率为 83 .87%和 80 .65 % ,不良反应发生率为 2 .86%和 0。两组的临床治愈率、有效率和真菌清除率及不良反应发生率差异均无显著性。但在治疗中 (第 1周 )试验组和对照组的有效率分别为 5 0 .0 0 %和 3 3 .3 3 % ,差异有非常显著性 (P <0 .0 0 5 )。结论 复方联苯苄唑乳膏治疗体股癣综合疗效和不良反应发生率与 1%联苯苄唑霜相似 ,但复方联苯苄唑乳膏治疗体股癣比 1%联苯苄唑霜起效快 ,具有很好的疗效和安全性。
Objective To evaluate the clinical efficacy and safety of compound bifonazole cream in the treatment of tinea corporis and tinea corporis. Methods Randomized double-blind, effective control, parallel group test, compared with 1% bifonazole cream control. Results A total of 67 cases of somatosensis were evaluated for efficacy evaluation, including 34 in the experimental group and 33 in the control group. The cure rate was 79.41% in the test group and 72.73% in the control group. The effective rates of the two groups were 85.29% and 81.82% respectively, the fungal clearance rates were 83.87% and 80.65%, and the incidence of adverse reactions was 2 .86% and 0. There was no significant difference in clinical cure rate, effective rate, fungal clearance rate and incidence of adverse reactions between the two groups. However, the effective rates of the experimental group and the control group during treatment (week 1) were 50.0% and 33.33%, respectively, with significant differences (P <0.05). Conclusion The combination bifuobenzole cream treatment of body tinea corporis and the incidence of adverse reactions were similar with 1% bifonazole cream, but compound bifonazole cream treatment of tinea corporis than 1% bifonazole cream Fast, with good efficacy and safety.