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目的:了解我院严重药品不良反应(ADR)发生的情况和特点,以促进合理用药。方法:对我院2006年1月～2008年9月收集到的21例严重ADR报告,按ADR因果关系判断标准进行分析、评价。结果:引起ADR例/次最多的是抗感染药,占52.38%;注射剂ADR构成比居首位,占80.95%;过敏性休克比例最高,占28.57%。结论:应加强合理用药意识,慎用注射剂,以减少和避免严重ADR的发生,保证药物治疗安全有效。
Objective: To understand the serious adverse drug reaction (ADR) in our hospital and the characteristics of the occurrence, to promote rational drug use. Methods: Twenty-one cases of serious ADR collected in our hospital from January 2006 to September 2008 were analyzed and evaluated according to the ADR causality criterion. Results: The most common cause of ADR cases was anti-infective drug, accounting for 52.38%. Injecting agent ADR constituted the first place, accounting for 80.95%. The highest proportion of allergic shock was 28.57%. Conclusion: Awareness of rational drug use should be strengthened and injections should be used with caution in order to reduce and avoid the occurrence of severe ADR and ensure safe and effective drug treatment.