Biomineralization:Biomimetic Synthesis of Materials and Biomimetic Regulation of Organisms

• 作 者: Zaiqiang Ma Benke Li Ruikang Tang
• 机 构: Department of Chemistry,Zhejiang University,Hangzhou,Zhejiang 310027,China;Department of Chemistry,Z
• 出 处: 中国化学（英文版）
• 发表日期: 2021年8期
• 关键词: Bioinorganic chemistry Biomimetic synthesis Biomineralization Materials science

The review summaries our achievements in biomineralization.A new under-standing of non-classical nucleation is introduced,which highlights the for-mation of ionic clusters during the early mineral formation.This discovery directs to a new chemical concept of inorganic ionic oligomers and their crosslinking.Different from the conventional syntheses of inorganic materials,the inorganic ionic oligomers can be used as the conformable precursors to achieve moldable constructions,which arises from a fusion of classic inorgan-ic and polymer chemistry by sharing the same process for the manufacture of materials.By using the inorganic oligomers,the biomimetic regenerations/repairs of hard tissues such as tooth enamel and bone can be realized.And the advanced artificial materials superior over biological ones can be devel-oped by inorganic-organic co-polymerization.Moreover,biomineralization is a tool for the integration of materials and biological organism.Our attempts demonstrate that the rationally designed materials-biologicals can contribute to vaccine improvement,universal blood transfusion,and cancer treatment,etc.They follow a transformation of biomineralization study from biomimetic synthesis of materials to biomimetic modification of organisms and furthermore,start an understanding of chemical biological regulation by materials.