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本实验通过小鼠耳廓肿胀法、及对阈下剂量戊巴比妥钠的协同作用 ,观察了小伏口服液的抗炎、镇静作用。结果表明小伏口服液 1g· kg- 1 和 2 g· kg- 1 对二甲苯所致的小鼠急性耳廓肿胀 (包含去除肾上腺法 )有明显的抑制作用 ;小伏口服液 1g· kg- 1 和 2 g· kg- 1 对给予阈下剂量戊巴比妥钠的小鼠有明显的协同作用。急性毒性实验表明小伏口服液最大耐受量 (小鼠灌胃 )为 2 40 g· kg- 1 (生药 ) ,相当于 70 kg成人临床用量的 5 60倍。小鼠腹腔注射 L D5 0 为 2 9.1936g· kg- 1 (生药 ) ,95 %可信限为 2 7.633～ 32 .417g· kg- 1。
In this experiment, the anti-inflammatory and sedative effects of Xiaofu oral liquid were observed through mouse ear swelling method and the synergistic effect of subthreshold dose of pentobarbital sodium. The results showed that the Xiaowei oral liquid 1g · kg-1 and 2g · kg-1 paraxylene induced acute ear swelling (including the removal of adrenal glands) has a significant inhibitory effect; Xiaofu oral liquid 1g · kg- 1 and 2 g·kg-1 had a clear synergistic effect on mice given subthreshold doses of sodium pentobarbital. Acute toxicity experiments showed that the maximum tolerated dose of Xiaofu Oral Liquid (mice gavage) was 2 40 g·kg-1 (crude drug), equivalent to 5 60 times the clinical dosage of 70 kg of adults. The intraperitoneal injection of L D50 in mice was 2 9.1936 g.kg-1 (crude drug) with a 95% confidence limit of 27.63 to 32.417 g.kg-1.