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目的监测重症监护病房(ICU)铜绿假单胞菌(Pseudomonas aeruginosa,PA)的感染状况及耐药变迁,指导临床合理使用抗菌药物。方法对2003年至2007年间,我院ICU收治的患者下呼吸道分泌物进行培养及体外耐药试验。结果铜绿假单胞菌是ICU下呼吸道感染的主导致病菌且感染率呈逐年上升的趋势(46.3%~81.0%),细菌对三代头孢、亚胺培南及氨基糖苷类药物的耐药性也呈逐年上升的趋势,并呈现多重耐药的特性。结论铜绿假单胞菌是ICU院内下呼吸道感染的常见病原菌,其多重耐药性及应引起高度重视。
Objective To monitor the infection status and drug resistance of Pseudomonas aeruginosa (ICU) in intensive care unit (ICU) and to guide the rational use of antimicrobial agents in clinic. Methods From 2003 to 2007, the lower respiratory tract secretions of ICU patients admitted to our hospital were cultured and tested in vitro. Results Pseudomonas aeruginosa was the main cause of lower respiratory tract infection in ICU and the infection rate showed a trend of rising year by year (46.3% ~ 81.0%). The resistance of bacteria to third generation cephalosporins, imipenem and aminoglycosides also Showing a trend of increasing year by year and showing multi-drug resistance characteristics. Conclusion Pseudomonas aeruginosa is a common pathogen of lower respiratory tract infection in hospital ICU, and its multidrug resistance should be paid more attention.