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目的探讨不同剂量速尿对耳蜗前庭作用的量效关系。方法利用手术破坏豚鼠的内淋巴囊，建立膜迷路积水动物模型，2月后随机等分为9组，A组静脉注射生理盐水作为对照组，其余各组分别静脉注射0．625～80mg／kg速尿，注射前后分别行前庭、耳蜗功能检查，并对耳蜗切片进行蜗管积水计算机定量分析。结果注射速尿剂量＞1．25mg／kg可明显改善积水耳前庭功能（P＜0．05），1．25～10mg／kg能显著降低ABR反应阈，但与剂量无显著相关。耳蜗积水定量分析发现，耳蜗脱水程度与剂量显著相关（P＜0．01）。结论静脉注射1．25mg／kg速尿有暂时改善膜迷路积水前庭功能的作用，此剂量无耳毒性，相当于成人每次注射20mg。
Objective To investigate the dose-effect relationship of different doses of furosemide on cochlear vestibular function. Methods The endolymphatic sac of guinea pigs was destroyed by operation, and the animal model of membranous labyrinth was established. After 2 months, rats were randomly divided into 9 groups. A group received normal saline as the control group, while the other groups received intravenous injection of 0.625-80 mg / kg furosemide, respectively, before and after injection vestibular, cochlear function tests, and cochlear hydrocephalus computer quantitative analysis. Results Injection furosemide dose> 1.25mg / kg can significantly improve the function of aqueous anastomosis vestibular (P <0.05), 1.25 ~ 10mg / kg can significantly reduce the ABR response threshold, but no significant correlation with the dose. Quantitative analysis of cochlear hydrocephalus found that the degree of cochlear dehydration and dose was significantly related (P <0.01). Conclusion Intravenous injection of 1.25 mg / kg furosemide has the effect of temporarily ameliorating vestibular function of the membranous labyrinth of hydronephrosis. This dose has no ototoxicity, equivalent to 20 mg per adult.