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采用放射免疫测定方法,对55例单一服用苯妥因钠治疗的癫痫患者及53例正常人进行了血清叶酸、Vit B_(12)浓度测定。根据服药时间,55例患者又分为三组:Ⅰ组为<1年,共21例;Ⅱ组为1～2年,共20例;Ⅲ组为>2年,共14例。结果显示:血清叶酸浓度均值,患者组显著低于对照组,Ⅰ组、Ⅱ组、Ⅲ组逐组降低,各组间差异统计学意义显著;Ⅰ组、Ⅲ组血清叶酸浓度异常发生率显著高于Ⅰ组,说明口服苯妥因钠可降低癫痫患者血清叶酸浓度,用药时间与血清叶酸浓度成反比,与血清叶酸浓度异常发生率成正比。血清Vit B_(12)浓度均值,患者组、Ⅰ组、Ⅱ组、Ⅲ组与对照组无显著差异。
Serum folic acid and Vit B 12 concentrations were measured in 55 patients with epilepsy treated with phenytoin sodium and 53 normal controls by radioimmunoassay. According to medication time, 55 patients were divided into three groups: Ⅰ group was <1 year, a total of 21 cases; Ⅱ group of 1 to 2 years, a total of 20 cases; Ⅲ group of> 2 years, a total of 14 cases. The results showed that the mean value of serum folate concentration was significantly lower in patients than in control group. The levels of serum folate in group Ⅰ, Ⅱ and Ⅲ were significantly lower than those in control group In group I, oral phenytoin sodium can reduce the concentration of serum folate in patients with epilepsy, medication time and serum folic acid concentration is inversely proportional to the incidence of abnormal serum concentrations of folic acid is proportional to. Serum Vit B_ (12) concentration in the patient group, Ⅰ group, Ⅱ group, Ⅲ group and the control group no significant difference.