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本文用交叉实验设计法研究了西咪替丁(Cim)对9只大鼠口服呋喃氟脲嘧啶(FT—207)药代动力学的影响。反相HPLC法测定血清FT-207浓度,其药时曲线符合一室开放模型。单次口服Cim80mg/kg或连用Cim80 mg/kg·d~(-1)×5d,均增加血清FT—207浓度和AUC。连用时,FT-207的C_(max)和AUC分别增加21.0%(P<0.05)和34.1%(P<0.025),Te_(1/2)缩短(P<0.005);单次服Cim时,FT-207的药代学改变与连用时相似,但差异无显著性。文中讨论了二药相互作用的机制及临床意义。
In this paper, the cross-experimental design was used to study the effects of cimetidine on pharmacokinetics of oral fuflufamide (FT-207) in nine rats. The concentration of FT-207 in serum was determined by reversed-phase HPLC. The curve of drug-concentration was consistent with the open-chamber model. A single oral Cim80mg / kg or Cim80mg / kg · d ~ (-1) × 5d, increased serum FT-207 concentration and AUC. The C_max and AUC of FT-207 increased by 21.0% (P <0.05) and 34.1% (P <0.025) and Te_ (1/2) shortened (P <0.005) Pharmacokinetic changes of FT-207 were similar to those of the combination, but the difference was not significant. The mechanism and clinical significance of interaction between two drugs are discussed in this article.