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目的观察腹腔镜术后辅助促性腺激素释放激素(Gn RHa)治疗子宫肌瘤的临床疗效。方法 108例择期行腹腔镜子宫肌瘤切除术的患者随机分为对照组与观察组,各54例。对照组采用单纯腹腔镜下子宫肌瘤切除术,观察组在对照组基础上术后第1次月经来潮的第1~3天于腹部前壁皮下注射醋酸戈舍瑞林缓释植入剂3.6 mg,3.6 mg/次,连续注射6次。结果两组治疗后子宫体积均较治疗前明显缩小,差异有统计学意义(P<0.05);术后24个月时,观察组子宫体积明显小于对照组,差异有统计学意义(P<0.05);观察组月经评分低于对照组,月经周期少于对照组,差异均有统计学意义(P<0.05);观察组复发率明显低于对照组(P<0.05)。结论腹腔镜术后辅助Gn RHa治疗子宫肌瘤能够降低术后的复发率,且能进一步缩小子宫体积,改善月经情况。
Objective To observe the clinical efficacy of laparoscopic assisted gonadotropin-releasing hormone (Gn RHa) in the treatment of uterine fibroids. Methods A total of 108 patients undergoing laparoscopic myomectomy were randomly divided into control group and observation group, 54 cases each. The control group was treated with simple laparoscopic myomectomy. The observation group was injected with goserelin acetate sustained-release implants in the anterior abdominal wall 1 to 3 days after the first menstrual cramp on the basis of the control group mg, 3.6 mg / time, continuous injection 6 times. Results After treatment, the uterine volume of the two groups was significantly reduced compared with that before treatment (P <0.05). At 24 months after operation, the uterine volume in the observation group was significantly smaller than that of the control group (P <0.05) ). The menstrual score of the observation group was lower than that of the control group, and the menstrual cycle was less than that of the control group (P <0.05). The recurrence rate of the observation group was significantly lower than that of the control group (P <0.05). Conclusion Laparoscopic surgery assisted Gn RHa treatment of uterine fibroids can reduce postoperative recurrence rate, and can further reduce the size of the uterus and improve menstrual conditions.