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目的分析泮托拉唑联合铝碳酸镁片治疗消化性溃疡的疗效及安全性。方法 100例消化性溃疡患者,根据治疗方案的不同分为对照组和观察组,各50例。全部患者给予基础治疗,对照组给予泮托拉唑治疗,观察组在对照组基础上嚼服铝碳酸镁片治疗。观察比较两组患者的临床效果、不良反应发生率及复发率。结果观察组总有效率为96.0%(48/50)高于对照组的84.0%(42/50),差异有统计学意义(χ~2=4.000,P=0.046<0.05)。两组不良反应发生率比较,差异无统计学意义(χ~2=0.211,P=0.646>0.05)。观察组复发率为10.0%(5/50)低于对照组的28.0%(14/50),差异有统计学意义(χ~2=5.263,P=0.022<0.05)。结论泮托拉唑联合铝碳酸镁片治疗消化性溃疡的临床效果好,安全可靠,复发率低,临床应用价值较高,值得推广。
Objective To analyze the efficacy and safety of pantoprazole and aluminum magnesium carbonate in the treatment of peptic ulcer. Methods One hundred patients with peptic ulcer were divided into control group and observation group according to the different treatment plans, 50 cases each. All patients were given basic treatment, the control group was treated with pantoprazole, and the observation group was treated with aluminum magnesium carbonate tablets on the basis of the control group. The clinical effects, incidence of adverse reactions and relapse rate were observed and compared between the two groups. Results The total effective rate was 96.0% (48/50) in observation group and 84.0% (42/50) in control group. The difference was statistically significant (χ ~ 2 = 4.000, P = 0.046 <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (χ ~ 2 = 0.211, P = 0.646> 0.05). The recurrence rate was 10.0% (5/50) in the observation group and 28.0% (14/50) in the control group. The difference was statistically significant (χ ~ 2 = 5.263, P = 0.022 <0.05). Conclusion The combination of pantoprazole and aluminum magnesium carbonate in the treatment of peptic ulcer has good clinical effect, safe and reliable, low recurrence rate and high clinical value, which deserves promotion.