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目的: 探讨小和微小肝癌的病理特点及其和MRI、彩色多谱勒超声( 简称彩超) 、肝动脉和门静脉造影诊断的关系.材料和方法: 应用大鼠肝癌模型进行MRI、彩超和肝动脉与门静脉造影, 并与组织病理对照.结果: 大于5M M 的癌灶主要为肝动脉供血, 门静脉在瘤体周边参与供血, 细胞分化相对较差,3 － 5 M M 的癌灶有动脉与门脉双重供血, 细胞分化高, 小于3M M 的癌灶以门静脉供血为主, 细胞分化高.大于5M M 的癌灶检出率MRI、HAA 和彩超为100 ％ , 而HPA 为75 ％ ;3 ~5 M M 的癌灶检出率彩超和MRI 为100 ％ 和95 ％ , HAA、HPA 为75 ％ 和85 ％ ; 2 ~3M M 的癌灶检出率MRI 较高 (71 .15 ％ ) 、HPA 和彩超为53 .85 ％ 和51 .92 ％ , HAA 为26 .92 ％ ;小于2 M M 的癌灶检出率HPA 较高为60 .78 ％ ,余均低.结论:小和微小肝癌( 小于5 M M ) 存在肝动脉和门静脉双重血供或以门静脉为主要血供是其病理特点,MRI 在检查小肝癌尤其微小肝癌方面优于彩超.“,”Purpose:To investigate the correlation among pathology and diagnosis of MRI,Doppuler US, hepatic arteriography and portovenography in small hepatocellular carcinomas.Materials and Methods:MRI,Color Doppler US,Hepatic arteriography and portovenography were performed in mice with hepatocellular carcinoma,and then undergone comparison with pathology.Results:The cells of carcinoma in 5mm diameter were mainly supplied by hepatic artery together with peripheral portal venous seeding and were usually in poor cell differentiation;the lesions bettween 3 to 5mm in diameter possessed both hepatic arterial and portal venous supplies often with high cell differentiation;those lesions less than 3mm in diameter were mainly supplied by portal veins with high cell differentiation.The detectabilities of MRI, Doppler US,HAA,HPA were 100%,100%,100%,75% respectively in lesions larger than 5mm;95%,100%,75%and 85%in lesions between 3 to 5mm;71.15%,51.92%,53.85%and 26.92% in lesions between 2 to 3mm.For lesions less than 2mm,the detectability by HPA was relatively high,others were fairly low.Conclusion:The blood supply of small or micro-hepatocellular carcinoma(<0.5mm)with both hepatic artery and portal veins or mainly by portal venis is the pathologic characteristics,MRI is more sensitive method for detection of small or micro-hepatocellular carcinoma than Doppler US.