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目的:观察腰方肌阻滞联合全身麻醉对经皮肾镜取石术患者痛敏反应及术后恢复的影响。方法:选取2016年1月至2020年1月期间本院收治的2000例结石直径>2 cm的肾结石患者，均予以标准经皮肾镜取石术治疗。按照不同的手术麻醉方式，将患者分为A组(腰方肌阻滞联合全身麻醉)和B组(全身麻醉)，每组各1000例。观察分析两组患者的术中血压变化、舒芬太尼用量与麻醉时间、术中脉率、血红蛋白、镇痛补救率及恢复时间，并观察两组患者的痛敏反应、结石清除率及并发症情况。结果:B组患者的麻醉时间长于A组，舒芬太尼用量大于A组，镇痛补救率高于A组，术后第1天的疼痛评分明显高于A组，差异均有统计学意义(n P2 cm admitted to our hospital were selected as the observation objects.They were all given standard percutaneous nephrolithotomy.According to the admission order, the patients were divided into group A(quadrate lumbar muscle block combined with general anesthesia) and group B (general anesthesia), with 1000 cases in each group.The intraoperative blood pressure changes, sufentanil dosage and anesthesia time, intraoperative pulse rate, hemoglobin, analgesic recovery rate, recovery time, and observe the hyperalgesia, stone clearance rate and complications of the two groups were observed and analyzed.Results:The anesthesia time of patients in group B was longer than that of group A, the dosage of sufentanil was greater than that of group A, the analgesic salvage rate was higher than that of group A, and the pain score on the first day after surgery was significantly higher than that of group A, the difference was statistically significant(n P<0.05). The incidence of intraoperative hypotension in group A was lower than that in group B(n P0.05). The SBP, DBP and pulse rate of group B at 90 min were higher than those before anesthesia(n P0.05).n Conclusions:In the treatment of percutaneous nephrolithotomy for patients with kidney stones, general anesthesia and quadratus lumbar muscle block combined with general anesthesia have similar effects, but quadratus lumbar muscle block combined with general anesthesia can significantly reduce the amount of anesthetics and reduce analgesic remedies At the same time, it will not adversely affect the blood pressure and pulse rate of the patient, and can reduce the hyperalgesia of the patient, promote the recovery of the patient, and has the value of promotion.