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目的观察新辅助化疗对结肠癌伴肠梗阻患者的疗效。方法 10例结肠癌伴肠梗阻的患者在常规保守疗法的基础之上,按FOLFOX4化疗方案给予新辅助化疗。结果 2例患者化疗中肠梗阻病情加重,终止化疗;8例患者肠梗阻得到了缓解,化疗中未见明显毒性反应。结论新辅助化疗可缓解结肠癌伴肠梗阻病情,为后继治疗创造有利条件。
Objective To observe the effect of neoadjuvant chemotherapy on patients with colon cancer and intestinal obstruction. Methods Ten patients with colon cancer and intestinal obstruction were treated with neoadjuvant chemotherapy on the basis of conventional conservative therapy according to the FOLFOX4 chemotherapy regimen. Results In 2 patients, intestinal obstruction was aggravated during chemotherapy and chemotherapy was terminated. Intestinal obstruction was relieved in 8 patients and no obvious toxic reaction was found in chemotherapy. Conclusion Neoadjuvant chemotherapy can relieve the condition of colon cancer with intestinal obstruction and create favorable conditions for subsequent treatment.