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目的探讨某些抗癫痫“中药制剂”中是否含有抗癫痫西药成分及其含量情况,指导临床用药。方法采用荧光偏振免疫法测定58例癫痫患者所服“中药制剂”中的丙戊酸钠、苯妥英钠、苯巴比妥、卡马西平的种类及血药浓度。结果所有患者中均检测出上述1～4种常用抗癫痫西药。血药平均浓度丙戊酸钠为(12±14)μg/ml,苯妥英钠为(5±6)μg/ml,苯巴比妥为(11±9)μg/ml,卡马西平为(2.2±2.6)μg/ml。结论所谓的抗癫痫“中药制剂”中含有不同种类和剂量的常用化学药物,干扰了癫痫的正规治疗。
Objective To investigate the anti-epilepsy “” Chinese medicine preparation “contains antiepileptic western medicine composition and content, to guide the clinical medication. Methods Fluorescence polarization immunoassay was used to determine the types and plasma concentrations of sodium valproate, phenytoin, phenobarbital and carbamazepine in 58 patients with epilepsy. Results All the patients were detected in the above 1 ~ 4 commonly used anti-epileptic western medicine. The average plasma concentration of sodium valproate was (12 ± 14) μg / ml, phenytoin sodium was (5 ± 6) μg / ml and phenobarbital was (11 ± 9) μg / ml and carbamazepine was ± 2.6) μg / ml. Conclusion The so-called anti-epilepsy ”“ Chinese medicine ”contains different types and doses of commonly used chemicals, interfering with the regular treatment of epilepsy.