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自然杀伤细胞(简称NK细胞)是一种较新近发现的免疫细胞,它在宿主抗恶性肿瘤、某些病毒性疾病和骨髓移植的免疫监视中可能起着重要的作用。过去对NK细胞的研究主要集中在肿瘤上,近年来NK细胞在抗病毒感染,特别是乙型肝炎中的地位也受到了重视,但研究报道不多,我们用~(125)I标记的尿嘧啶核苷(~(125)IudR)标记的k562细胞作为靶细胞,对住院22例不同类型乙型病毒性肝炎者外周血中NK细胞的活性进行了检测。其中男16例,女6例。急性黄疸型8例(急性期早期5例,恢复期3例),慢迁肝3例,慢活肝9例,无症状HBsAg携带者2例。结
Natural killer cells (NK cells for short) are relatively recently discovered immune cells that may play an important role in immune surveillance of host anti-malignant tumors, certain viral diseases and bone marrow transplants. In the past, the study of NK cells mainly focused on tumors. In recent years, the role of NK cells in antiviral infections, especially hepatitis B, has been emphasized. However, few reports have been reported. We used ~ (125) I labeled urine The cytotoxic activity of NK cells in peripheral blood of 22 patients with different types of hepatitis B in hospital was detected by using karyotyping of ~ (125) IudR labeled k562 cells as target cells. There were 16 males and 6 females. Acute jaundice in 8 cases (early acute phase in 5 cases, convalescence in 3 cases), 3 cases of slow-moving liver, 9 cases of slow-living liver, 2 cases of asymptomatic HBsAg carriers. Knot