insulin-like growth factor-i enhances gut growth and improves mucosal barrier function in sepric rat

• 作 者: Kai Chen M.D Toshitada Okuma M.D Kenji Okamura M.D Yoahimasa Miyauchi M.D
• 机 构: First Dept of Surgery,Kumamoto University School of Medicine,Kumamoto 860,Japan.,First Dept of Surge
• 出 处: 中国临床营养杂志
• 发表日期: 1994年04期
• 关键词: mucosal metabolism parenteral altered Insulin sepsis nutrition implicated somati

Sepsis causes gut mucosal metabolic derangem-ints and has been implicated in altered barrier func-tion.Insulin-like growth factor-I(IGF-I)has beenshown to accelerate somatic growth,as well as to in-duce growth of the gut.To investigate the effect ofIGF-I on gut mucosal metabolism and barrier functionin sepsis,32 male wistar rats underwent cecal ligationwere randomized to 2 groups:IGF-I(n=17)re-ceived parenteral nutrition(PN)plus IGF-I 4mg.kg.~(-1)d~(-1)and control group(n=15)received PNonly,or 3 days.On day 4,body weight(BW)gain,

Sepsis causes gut mucosal metabolic derangem-ints and has been implicated in altered barrier func- tion. Insulin-like growth factor-I (IGF-I) has been sholed to accelerate somatic growth, as well as to in-duce growth of the gut. To investigate the effect of IGF-I on gut mucosal metabolism and barrier function in sepsis, 32 male wistar rats underwent cecal ligationwere randomized to 2 groups: IGF-I (n = 17) re-ceived parenteral nutrition (PN) plus IGF-I 4mg. (-1) and control group (n = 15) received PNonly, or 3 days. On day 4, body weight (BW) gain,