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心血管的组织内肾素－血管紧张素系统在心血管疾病的病理发展中起着重要作用。血管紧张素Ⅱ（ＡⅡ）是肾素－血管紧张素系统的关键成分，其除对心脏有短期的正性变力作用外，还有长期的致肥厚与重构作用。心血管局部存在三条ＡⅡ生成途径：胃促胰酶（ｃｈｙｍａｓｅ，Ｃｈｙ）途径、血管紧张素Ⅰ转化酶（ａｎｇｉｏｔｅｎｓｉｎｃｏｎｖｅｒｔｉｎｇｅｎｚｙｍｅ，ＡＣＥ）途径和一种被称为Ｎａｆａｍｏｓｔａｔ敏感的途径。由这些途径生成的ＡⅡ都参与缺血、缺氧时心血管的病理变化。近来发现ＡＴ２受体介导抗增殖效应，而ＡＴ１受体拮抗剂逆转心血管肥厚的作用机制可能与此有关。本文对有关的研究结果进行了介绍
Cardiovascular tissue renin-angiotensin system plays an important role in the pathological development of cardiovascular diseases. Angiotensin II (AII) is a key component of the renin-angiotensin system and has a long-term effect on hypertrophy and remodeling, in addition to its short-term positive anaplastic effects on the heart. There are three pathways of AII production in the cardiovascular area: the chymase (Chy) pathway, the angiotensin-converting enzyme (ACE) pathway and a pathway called Nafamostat. AII generated by these pathways is involved in the pathological changes of the cardiovascular system during ischemia and hypoxia. AT2 receptors have recently been found to mediate anti-proliferative effects, and the mechanism by which AT1 receptor antagonists reverse cardiovascular hypertrophy may be involved. This article describes the relevant research results