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本文以烟雾刺激（每日２小时共三个月）复制地鼠呼吸道炎症模型并观察中药制剂对其保护作用。结果表明，烟雾刺激三个月，使地鼠的支气管肺泡灌洗液（ＢＡＬＦ）中的蛋白含量、红细胞（ＲＢＣ）、中性粒细胞（ＰＭＮｓ）计数明显增加：丙二醛（ＭＤＡ）含量及β－葡萄糖醛酸酶（β－ｇ）活性也明显增高（均Ｐ＜０．０１）；但肺动脉压及右心室／（左心室十室间隔）比值［Ｐ／（Ｌ＋Ｓ）］无明显变化以上结果提示，烟雾刺激三个月只引起地鼠呼吸道炎症反应，并有炎性细胞聚集和活化。而对肺动脉压及右心功能无明显影响。中药制剂（甘草、连翘、山豆根复方制剂酒精提取物，每日灌胃１ｍＬ／１００ｇ体重共三个月）对上述呼吸道炎症有明显保护作用，使ＢＡＬＦ中的蛋白含量降低，红细胞及ＰＭＮｓ计数明显减少。ＭＤＡ含量降低，β－ｇ活性也明显降低（均Ｐ＜０．０１）。讨论了中药制剂疗效的可能机理。
In this paper, aerosol irritation (2 hours a day for three months) replicated hamster respiratory inflammation model and observed the Chinese medicine preparation to its protective effect. The results showed that the protein content, RBC and PMNs in BALF were significantly increased in hamsters after three months’ stimulation: malondialdehyde (MDA) content and β-g-glucuronidase (β-g) activity was also significantly increased (all P <0.01); but the pulmonary artery pressure and right ventricular / (left ventricular interventricular septum) ratio [P / The results suggest that smoke-induced irritation in the respiratory tract of hamsters for three months only causes inflammatory cell aggregation and activation. No significant effect on pulmonary artery pressure and right heart function. The traditional Chinese medicine preparations (alcoholic extract of licorice, forsythia and shaddou root compound, daily gavage of 1mL / 100g body weight for three months) have significant protective effect on the inflammation of the respiratory tract and reduce the protein content in the BALF. The red blood cells and the PMNs The count is significantly reduced. MDA content decreased, β-g activity was significantly lower (both P <0.01). Discuss the possible mechanism of curative effect of traditional Chinese medicine.