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目的: 检测早期梅毒患者血清 IL-37 和 IL-38 的水平. 方法: 采用酶联免疫吸附法( ELISA)检测140例早期梅毒患者和180例正常对照血清IL-37、IL-38的表达水平. 结果: 早期梅毒患者血清中IL-37和IL-38的中位数分别为14.15 pg/mL和12.21 pg/mL,正常对照组分别为31.76 pg/mL和17.09 pg/mL,差异均有统计学意义(均P<0.005). 结论: 早期梅毒患者外周血清中IL-37和IL-38降低,可能与梅毒患者细胞免疫相关.“,”Objective:To detect the serum level of IL-37 and IL-38 in the patients with early syphilis. Methods:The level of IL-37 and IL-38 was detected with ELISA in 140 patients with early syphilis and 180 healthy controls. Results:The medians of IL-37 and IL-38 in patients of early syphilis were 14. 15 pg/mL and 12.21 pg/mL, which was lower than those of in healthy controls 31.76 pg/mL and 17.09 pg/mL (均P<0.05) . Conclusion:The level of IL-37 and IL-38 is lower in the patients with early syphilis, indicating that IL-37 and IL-38 may be involved in the cellular immunity.