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目的观察阿托伐他汀对不稳定型心绞痛(UAP)患者血清高敏C-反应蛋白(hs-CRP)、基质金属蛋白酶-9(MMP-9),内皮素-1(ET-1)、总胆固醇(TC)、甘油三脂(TG)的影响。方法将85例住院治疗的UAP患者分为常规治疗组(37例)和常规加阿托伐他汀治疗组(48例),给予阿托伐他汀20 mg/d共14 d,治疗前后测定两组TC、TG、hs-CRP、MMP-9、ET-1水平并进行比较。结果治疗组治疗后TC、TG、hs-CRP、MMP-9、ET-1水平低于对照组,差异有统计学意义(P<0.05)。结论短期应用阿托伐他汀治疗UAP可以抑制炎症反应,改善内皮功能,稳定动脉粥样硬化斑块,减少冠脉事件发生。
Objective To observe the effects of atorvastatin on serum hs-CRP, MMP-9, ET-1, total cholesterol in patients with unstable angina pectoris (UAP) (TC), triglyceride (TG). Methods Eighty-five inpatients with UAP were divided into routine treatment group (n = 37) and conventional atorvastatin treatment group (n = 48). Atorvastatin 20 mg / d was given for 14 days. Before and after treatment, TC, TG, hs-CRP, MMP-9, ET-1 levels were compared and compared. Results The levels of TC, TG, hs-CRP, MMP-9 and ET-1 in the treatment group were lower than those in the control group after treatment (P <0.05). Conclusions Short-term use of atorvastatin in treatment of UAP can inhibit the inflammatory response, improve endothelial function, stabilize atherosclerotic plaque and reduce the occurrence of coronary events.