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现有资料表明,应用最广泛的降压药噻嗪类利尿剂,降压效果相似选择性α_2受体阻滞剂哌唑嗪.但噻嗪类利尿剂治疗的高血压患者中,大约30%发生低血钾(<3.5毫摩/升),与剂量有关,伴有室性心律失常增加.噻嗪类治疗还可使尿酸增加1.0～2.0毫克/分升,长程治疗者中大约5%发生痛风.噻嗪类利尿剂的最重要缺点是对血脂代谢产生不利影响:使总胆固醇、低密度脂蛋白胆固醇(LDL-C)和甘油三酯浓度增加:这一不利影响与β阻滞剂呈相加. 相反,α阻滞剂不影响血清电解质、尿酸或精耐量.选择性α_1阻滞剂哌唑嗪,对血脂代谢无不良影响;有些研究结果表明,它使血浆胆固醇浓度下降,从而改善总胆固醇/高密度脂蛋白胆固醇
Available data show that the most widely used antihypertensive drugs thiazide diuretics, antihypertensive effect similar to the selective α 2 receptor blocker prazosin, but thiazide diuretics in hypertensive patients, about 30% Hypokalemia occurs (<3.5 mmol / L) and is dose-related with an increase in ventricular arrhythmias. Thiazide therapy also increases uric acid by 1.0-2.0 mg / dL, and approximately 5% of long-term treatment occurs Gout. The most important drawbacks of thiazide diuretics are the adverse effects on blood lipid metabolism: an increase in total cholesterol, low density lipoprotein cholesterol (LDL-C) and triglycerides: this adverse effect is associated with a decrease in beta-blocker In contrast, alpha blockers do not affect serum electrolytes, uric acid, or tolerance.Phazalizine, a selective alpha 1 blocker, has no adverse effect on lipid metabolism; some studies have shown that it decreases plasma cholesterol levels and thus improves Total Cholesterol / High Density Lipoprotein Cholesterol