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目的测查早产儿过氧化脂质,探讨早产儿是否存在过氧化损害。方法43名早产儿及32名足月儿生后24h以内取血,采用的FBA比色法为改良的八木国夫法测定脂质过氧化物(LPO)。结果早产儿LPO值(5.99-11.92nmol/ml)明显高于正常新生儿(4.25nmol/ml),胎龄愈小,体重愈轻,LPO值愈高。LPO与胎龄、出生体重呈高度负相关,双胎早产儿LPO值更高。结论本组结果提示早产儿体内存在过氧化损害,为临床上早产儿应用VitE、VitC及超氧化歧化酶(SOD)等自由基清除剂提供了理论依据。
Objective To investigate lipid peroxidation in preterm infants and explore whether there is peroxidative damage in preterm infants. Methods Forty - three premature infants and 32 full - term infants were drawn blood within 24 hours after their birth. The lipid peroxides (LPO) were determined by modified FABA colorimetric method. Results LPO value (5.99-11.92nmol / ml) in preterm infants was significantly higher than that in normal neonates (4.25nmol / ml). The smaller the gestational age, the lighter the body weight, the higher the LPO value. LPO and gestational age, birth weight was highly negatively correlated, twin preterm LPO value higher. Conclusion The results of this study suggest that peroxisome damage exists in preterm infants and provide a theoretical basis for the use of free radical scavengers such as VitE, VitC and superoxide dismutase (SOD) in preterm infants.