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目的了解肺癌患者肺部非发酵菌感染的病原学构成及耐药特征,为非发酵菌感染的预防和治疗提供有效依据。方法对本院2009年7月至2014年6月肺癌并发肺部非发酵菌感染的病例进行回顾分析,常规方法培养及鉴定细菌,K-B法检测非发酵菌的耐药率,按CLSI 2013年标准判定药敏结果,用WHONET 5.6软件分析数据,研究其病原菌构成及耐药特征。结果 2009年7月至2014年6月,从本院住院治疗的肺癌合并肺部感染患者中共检出非发酵菌211株,其中铜绿假单胞菌最为常见(42.2%),其次为鲍氏不动杆菌(28.9%)和嗜麦芽寡养单胞菌(20.4%);药敏试验表明4种非发酵菌对常用抗菌药物均有不同程度的耐药甚至多重耐药。结论非发酵菌是导致肺癌合并肺部感染常见病原菌,其耐药率高,治疗困难,临床应高度重视,加强耐药性监测,为临床合理用药,防止继发感染提供依据。
Objective To understand the etiological composition and drug resistance of pulmonary non-fermentive bacterial infections in lung cancer patients, and to provide an effective basis for the prevention and treatment of non-fermentative bacterial infections. Methods The hospital from July 2009 to June 2014 lung cancer complicated with non-fermentive bacterial infections were retrospectively analyzed. Bacteria were cultured and identified by routine methods. The drug resistance rate of non-fermentative bacteria was detected by KB method. According to CLSI 2013 standard To determine the susceptibility results, WHONET 5.6 software analysis of data to study the pathogens and drug resistance characteristics. Results From July 2009 to June 2014, 211 strains of non-fermentative bacteria were detected in hospitalized patients with lung cancer complicated with lung infection, of which Pseudomonas aeruginosa was the most common (42.2%), followed by Baldor Acinetobacter (28.9%) and Stenotrophomonas maltophilia (20.4%). The results of drug susceptibility test showed that the four non-fermenting bacteria had different degrees of resistance or even multi-drug resistance to common antibacterials. Conclusion Non-fermentative bacteria are common pathogens causing lung cancer complicated with pulmonary infection. The rate of drug resistance is high, treatment is difficult, and clinical treatment should be taken seriously. Non-fermentative bacteria should be strengthened to monitor the drug resistance for clinical rational use and prevention of secondary infection.