The progress in optic nerve regeneration, where are we?

• 作 者: Jennifer Wei Huen Shum Kwok-fai So
• 机 构: Department of 0phthalmology, The University of Hong Kong, Hong Kong Special Administrative Region, C
• 出 处: 中国神经再生研究（英文版）
• 发表日期: 2016年1期
• 关键词: optic nerve regeneration axonal regeneration neurotrophic factor inflammatory st

Optic nerve regeneration is an important area of research. It can be used to treat patients suffering from optic neuropathy and provides insights into the treatment of numerous neurodegenerative diseases. There are many hurdles impeding optic regeneration in mammals. The mammalian central nervous system is non-permissive to regeneration and intrinsically lacks the capacity for axonal regrowth. Any axonal injury also triggers a vicious cycle of apoptosis. Understanding these hurdles provides us with a rough framework to appreciate the essential steps to bring about optic nerve regeneration: enhancing neuronal survival, axon regeneration, remyelination and establishing functional synapses to the original neuronal targets. In this review article, we will go through current potential treatments for optic nerve regeneration, which includes neurotrophic factor provision, inlfammatory stimulation, growth inhibition suppression, intracellular sig-naling modiifcation and modeling of bridging substrates.