Roles of neural stem cells in the repair of peripheral nerve injury

• 作 者: Chong Wang Chang-feng Lu Jiang Peng Cheng-dong Hu Yu Wang
• 机 构: Central Hospital of Handan, Handan, Hebei Province, China“,”Institute of Orthopedics, Chinese PLA Ge
• 出 处: 中国神经再生研究（英文版）
• 发表日期: 2017年12期
• 关键词: nerve regeneration neural stem cells peripheral nerve regeneration Schwann-like

Currently, researchers are using neural stem cell transplantation to promote regeneration after peripher-al nerve injury, as neural stem cells play an important role in peripheral nerve injury repair. This article reviews recent research progress of the role of neural stem cells in the repair of peripheral nerve injury. Neural stem cells can not only differentiate into neurons, astrocytes and oligodendrocytes, but can also differentiate into Schwann-like cells, which promote neurite outgrowth around the injury. Transplanted neural stem cells can differentiate into motor neurons that innervate muscles and promote the recovery of neurological function. To promote the repair of peripheral nerve injury, neural stem cells secrete various neurotrophic factors, including brain-derived neurotrophic factor, fibroblast growth factor, nerve growth factor, insulin-like growth factor and hepatocyte growth factor. In addition, neural stem cells also promote regeneration of the axonal myelin sheath, angiogenesis, and immune regulation. It can be concluded that neural stem cells promote the repair of peripheral nerve injury through a variety of ways.