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In recent years,Percutaneous coronary intervention(PCI) as an effective treatment for coronary heart disease has been widely carried out in China.However,people is still confronted with the problem that the incidence of in-stent restenosis (ISR) after PCI.Some risk factors of coronary heart disease have been obviously known,but the in-dependent predictor factors for the ISR has not been clear.Clarifying risk factors for ISR to establish interfering meas-ures may be a new direction for PCI treatment in the future.At present,it has been reported that aldosterone (ALD) may be involved in ISR.In order to further investigate the relationship between the serum ALD levels and ISR,our re-search was to determine the ALD and other serum markers to explore the impact factors of ISR.Methods We meas-ured serum ALD,high sensitivity C-reactive protein (hs-CRP) ,adiponectin (ADP) and other indicators in 258 pa-tients with coronary stenting,and made routine follow-up for 6-9 months to perform coronary angiography.According to the results of coronary angiography,all patients were divided into restenosis group and non-restenosis group.We an-alyzed the relationship between ALD,other indicators and ISR to explore whether serum ALD was an independent risk factor ISR.Results Serum ALD levels were significantly higher in restenosis group than non-restenosis group.Logis-tic regression analysis showed that diabetes,ALD,hs-CRP and complex lesions were also independent risk factors for ISR (P < 0.05) ,while the ADP was as a protective factor for ISR (P < 0.05) .Conclusions ALD is one of inde-pendent risk factors for ISR after undergoing coronary stent implantation in patients.It has the possibility of becoming one new method in this medical field.
Percutaneous coronary intervention (PCI) as an effective treatment for coronary heart disease has been widely carried out in China. Still, people is still confronted with the problem that the incidence of in-stent restenosis (ISR) after PCI.Some risk factors of coronary heart disease have been significantly known, but the in-dependent predictor factors for the ISR has not been clear. Clarifying risk factors for ISR to establish interfering meas-ures may be a new direction for PCI treatment in the future. At present, it has been reported that aldosterone (ALD) may be involved in ISR. order to further investigate the relationship between the serum ALD levels and ISR, our re-search was to determine the ALD and other serum markers to explore the impact factors of ISR. Methods We measurable serum ALD, high sensitivity C-reactive protein (hs-CRP), adiponectin (ADP) and other indicators in 258 pa- tients with coronary stenting, and made routine follow-up for 6-9 months to perform coronary angiography. According to the results of coronary angiography, all patients were divided into restenosis group and non-restenosis group. We an-alyzed the relationship between ALD, other indicators and ISR to explore whether serum ALD was an independent risk factor ISR. Results Serum ALD levels were significantly higher in restenosis group than non-restenosis group. Logis-tic regression analysis showed that diabetes, ALD, hs-CRP and complex lesions were also independent risk factors for ISR (P <0.05), while the ADP was as a protective factor for ISR (P <0.05) .Conclusions ALD is one of the inde-pendent risk factors for ISR after undergoing coronary stent implantation in patients. It has the potential of becoming one new method in this medical field.