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目的：探讨细胞粘附分子CD62P在结直肠癌患者癌组织和血浆中的表达及其临床意义。方法：采用免疫组化LSAB法检测CD62P在58例结直肠癌或腺瘤患者的肿瘤组织及10例正常对照者结直肠粘膜组织中的表达，用酶联免疫吸附测定（ELISA）法检测其中24例患者的血浆CD62P水平。结果：CD62P在结直肠癌组织中的表达显著升高，并与Dukes分期和肿瘤转移明显相关；组织CD62P阳性患者的血浆CD62P水平显著高于组织CD62P阴性者。结论：CD62P与结直肠癌转移密切相关，可望成为预测结直肠癌转移和预后的良好指标。
Objective: To investigate the expression of cell adhesion molecule CD62P in the cancer tissue and plasma of patients with colorectal cancer and its clinical significance. Methods: The expressions of CD62P in colorectal mucosa of 58 patients with colorectal cancer or adenoma and 10 normal controls were detected by immunohistochemical LSAB method. The expression of CD62P was detected by enzyme linked immunosorbent assay (ELISA) Cases of patients with plasma CD62P levels. Results: The expression of CD62P in colorectal cancer was significantly increased, which was significantly correlated with Dukes staging and tumor metastasis. The level of CD62P in patients with CD62P positive was significantly higher than that in patients with CD62P negative. Conclusion: CD62P is closely related to the metastasis of colorectal cancer, which is expected to be a good predictor of colorectal cancer metastasis and prognosis.