,Exploring the utility of the Chasing Principle: influence of drug-free SNEDDS composition on solubi

• 作 者: Scheyla Daniela Siqueira J(φ)rgensen Thomas Rades Huiling Mu Kirsten Graeser Anette Müllertz
• 机 构: Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen
• 出 处: 药学学报（英文版）
• 发表日期: 2019年1期
• 关键词: Self-nanoemulsiying drug delivery system (SNEDDS) Chasing principle Two-compartm

This study assessed the influence of the composition of drug-free SNEDDS co-dosed with aqueous suspensions of carvedilol (CAR),cinnarizine (CIN) or R3040 on drug solubilization in a twocompartment in vitro lipolysis model.Correlation of drug logP or solubility in SNEDDS with drug solubilization during in vitro lipolysis in the presence of drug-free SNEDDS was assessed.SNEDDS with varying ratios of soybean oil∶Maisine 35-1 (1∶1,w/w) and Kolliphor RH40,with ethanol at 10％ (w/w) were used.SNEDDS were named F65,F55 and F20 (numbers refer to the percentage of lipids) and aqueous suspensions without drug-free SNEDDS (F0) were also analyzed.While the ranking order of drug solubilization was F65 =F55 =F20 ＞ F0 for CAR;F65 =F55 ＞ F20 ＞ F0 for CIN and F65 =F55 =F20 ＞ F0 for R3040-with higher CAR solubilization than for R3040 and CIN-the ranking of Seq of CAR,CIN and R3040 in SNEDDS was F65 ＜ F55 ＜ F20,F65 =F55 ＞ F20 and F65 ＞ F55 ＞ F20,respectively.Therefore,the composition of SNEDDS influenced the solubilization of CIN,but not CAR and R3040.Furthermore,high Seq in SNEDDS did not reflect high drug solubilization.As CAR (logP 3.8) showed higher solubilization than CIN (logP 5.8) and R3040 (logP 10.4),a correlation between drug logP and drug solubilization was observed.