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目的探讨阿奇霉素序贯疗法对小儿肺炎支原体肺炎(MPP)的疗效。方法将92例MPP患儿随机分为2组:治疗组47例,对照组45例。2组患儿除均予综合治疗外,对照组静脉滴注注射用乳糖酸红霉素治疗,30 mg.kg-1.d-1,应用10～14 d;治疗组采用阿奇霉素序贯疗法治疗,即静脉滴注阿奇霉素(10 mg.kg-1.d-1,应用3～5 d)后口服阿奇霉素干混悬剂(10 mg.kg-1.d-1,应用7 d)。比较2组疗效、不良反应发生情况体征消失时间以及住院时间。结果对照组总有效率为77.78%,治疗组总有效率为95.74%,治疗组疗效显著优于对照组(P<0.05)。治疗组不良反应发生率为21.28%,对照组不良反应发生率为55.56%,治疗组不良反应的发生率显著低于对照组(P<0.05);治疗组体征消失时间和住院时间均显著少于对照组(Pa<0.05)。结论采用阿奇霉素序贯疗法治疗小儿MPP的效果显著。
Objective To investigate the effect of sequential therapy of azithromycin on children with Mycoplasma pneumoniae pneumonia (MPP). Methods Ninety-two children with MPP were randomly divided into two groups: treatment group (n = 47) and control group (n = 45). In addition to the two groups were given comprehensive treatment, the control group intravenous infusion of erythromycin lactobionate treatment, 30 mg.kg-1.d-1, application of 10 ~ 14 d; the treatment group treated with azithromycin sequential therapy , Namely azithromycin (10 mg.kg-1.d-1 for 7 d) after intravenous azithromycin (10 mg.kg-1.d-1 for 3 ~ 5 d). The curative effects of two groups were compared, and the disappearance time of signs and hospitalization time were compared. Results The total effective rate of the control group was 77.78%, the total effective rate of the treatment group was 95.74%, the treatment group was significantly better than the control group (P <0.05). The incidence of adverse reactions in the treatment group was 21.28%, the incidence of adverse reactions in the control group was 55.56%, the incidence of adverse reactions in the treatment group was significantly lower than that in the control group (P <0.05); the disappearance time and hospitalization time in the treatment group were significantly less than Control group (Pa <0.05). Conclusion Sequential azithromycin treatment of children with significant effect of MPP.