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给 Wistar 雌性未孕大鼠隔日注射苯甲酸雌二醇(0.8mg/kg,共10次),复制乳腺增生病模型,结果发现模型组大鼠乳房增大,乳腺增生呈弥漫性,乳腺腺泡和小叶显著增加,腺泡腔和腺导管腔明显扩张;血清雌二醇(E_2)水平显著升高,孕酮(P)、睾酮(T)及催乳素(PRL)水平无明显变化;血清超氧化物歧化酶(SOD)活性明显降低,丙二醛(MDA)含量显著增加;大鼠胸腺和脾脏均明显萎缩,子宫则明显肿大。提示 E_2水平升高可能是引起乳腺增生病的主要原因;SOD 活性降低和 MDA 含量增加可能也是引起乳腺增生病的原因之一;胸腺和脾脏萎缩,亦会促进乳腺增生病的发展。这为筛选和研究治疗乳腺增生病的有效方药提供一种稳定的动物病理模型和一些反映病因的客观观察指标。
Female Wistar female rats were injected intraperitoneally with estradiol benzoate (0.8 mg / kg, 10 times) for the first time, and the model of mammary gland hyperplasia was duplicated. The results showed that the mammary enlargement, diffuse mammary gland hyperplasia, (P <0.05), the level of progesterone (P), testosterone (T) and prolactin (PRL) did not change significantly. Serum The activity of superoxide dismutase (SOD) was significantly decreased and the content of malondialdehyde (MDA) was significantly increased. The thymus and spleen of rats were atrophy and the uterus was obviously enlarged. It suggests that the increase of E_2 may be the main reason of breast hyperplasia. The decrease of SOD activity and the increase of MDA content may be one of the causes of breast hyperplasia. The atrophy of thymus and spleen may also promote the development of mammary gland hyperplasia. This provides a stable animal pathological model for screening and studying effective prescriptions for treating hyperplasia of mammary glands and some objective observation indicators reflecting the etiology.