论文部分内容阅读
目的:了解生殖道人乳头瘤病毒高危型(HPV16/18)感染与宫颈病变、宫颈癌的关系,以便早期发现和治疗宫颈上皮内瘤样变(CIN)和原位癌。方法:利用膜式液基薄层细胞学(TCT)技术筛查与病理学诊断相结合,以宫颈炎为对照组,对宫颈炎和高危患者(如ASCUS、CIN、宫颈原位癌)共685例进行HPV16/18型荧光定量PCR检测。结果:高危患者中HPV16/18感染率为64.2%(124/193),其中宫颈癌、CINⅢ和CINⅡ的HPV16/18感染率为97.2%(69/71),CIN感染率为52.0%(26/50),ASCUS感染率为40.3%(29/72),宫颈炎对照组感染率为11.2%(55/492),宫颈炎和高危患者两组结果比较有统计学差异(P<0.005),高危患者中<40岁感染率为69.0%(40/58),≥40岁感染率为62.2%(84/135),两组结果比较无统计学差异(P>0.05)。结论:高危型HPV16/18感染与宫颈病变,特别是宫颈癌、宫颈癌前病变的发生有明显的相关性,并且病变越重,HPV的感染率越高。提示宫颈癌的防治重点应放在高危型HPV感染者,并且宫颈病变的发生与年龄无相关性。
Objective: To understand the relationship between HPV16 / 18 infection and cervical lesions and cervical cancer in order to detect and treat cervical intraepithelial neoplasia (CIN) and carcinoma in situ early. Methods: The combination of membranous liquid-based cytology (TCT) screening and pathological diagnosis was used to detect cervicitis as the control group, and 685 cervicitis patients and high-risk patients (such as ASCUS, CIN and cervical carcinoma in situ) Cases of HPV16 / 18 type fluorescence quantitative PCR test. Results: The HPV16 / 18 infection rates in high risk patients were 64.2% (124/193). The HPV16 / 18 infection rates in cervical cancer, CINⅢ and CINⅡ were 97.2% (69/71) and 52.0% (26 / 50). The infection rate of ASCUS was 40.3% (29/72). The infection rate of cervicitis control group was 11.2% (55/492). The results of cervicitis and high risk group were statistically significant (P <0.005) The prevalence of infection at age <40 was 69.0% (40/58) in patients and 62.2% (84/135) at ≥40 years. There was no significant difference between the two groups (P> 0.05). CONCLUSION: High-risk HPV16 / 18 infection has obvious correlation with cervical lesions, especially cervical cancer and cervical precancerous lesions, and the more severe lesions, the higher the HPV infection rate. Tip prevention and treatment of cervical cancer should focus on high-risk HPV infection, and the occurrence of cervical lesions and age were not related.