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全肝缺失时血浆直链氨基酸进行性增加,但支链氨基酸轻度降低。在人类慢性肝脏衰竭时可观察到类似的异常。血浆浓度最高者为蛋氨酸、苯丙氨酸、酪氨酸、门冬氨酸和谷氨酸,升高2～4倍。急性暴发性肝脏衰竭中,除支链氨基酸外,血浆中全部氨基酸的浓度均有相当的增高,以蛋氨酸增高最显著,可高至27倍。在脑脊液中,谷氨酰胺最为突出,其绝对浓度至少为任何其它的氨基酸的20倍。但在急性肝昏迷中,蛋氨酸、酪氨酸、苯丙氨酸、组氨酸和脯氨酸相对增高多一些。
Linear hepatic plasma amino acid progressively increased when the liver was deficient, but the branched-chain amino acids decreased slightly. A similar abnormality can be observed in chronic liver failure in humans. The highest plasma concentrations of methionine, phenylalanine, tyrosine, aspartic acid and glutamic acid, increased 2 to 4 times. In acute fulminant hepatic failure, except for the branched-chain amino acids, the concentrations of all the amino acids in plasma are considerably increased, with the most significant increase being methionine, up to 27 times. In cerebrospinal fluid, glutamine is the most prominent, its absolute concentration of at least 20 times that of any other amino acids. However, in acute hepatic coma, methionine, tyrosine, phenylalanine, histidine and proline relative increase more.