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目的调查住院和门诊COPD患者中OSAS的患病率及OSAS患者中COPD的患病率,探讨COPD与OSAS之间的关系,分析重叠综合征患者睡眠呼吸紊乱的特点。方法对200例稳定期的COPD患者经问卷、爱波沃斯(ESS)评分及家庭血氧饱和度监测,对氧减饱和指数大于5或爱波沃斯(ESS)评分大于或等于10的患者进行多导生理记录仪睡眠呼吸监测(PSG)。结果门诊COPD患者中OSAS的患病率为2.5%,住院COPD患者中OSAS患病率为6.7%,OSAS患者中COPD的患病率为11.2%。重叠综合征患者与单纯OSAS患者在夜间平均氧饱和度、呼吸暂停指数、低通气指数等方面差异有显著性(P<0.01)。结论COPD与OSAS两者之间没有必然联系,重叠综合征患者夜间呼吸紊乱模式以肺泡通气不足和肺泡低通气为主而非呼吸暂停,重叠综合征患者睡眠中低氧程度比单纯OSAS患者更严重。
Objective To investigate the prevalence of OSAS in hospitalized and outpatient COPD patients and the prevalence of COPD in OSAS patients. To explore the relationship between COPD and OSAS and to analyze the characteristics of sleep-disordered breathing in patients with overlapping syndrome. Methods 200 patients with stable COPD were monitored by questionnaire, ESS score and family oxygen saturation. Patients with Oxygen desaturation index greater than 5 or ESS score greater than or equal to 10 Conducted polysomnography sleep apnea monitoring (PSG). Results The prevalence of OSAS in outpatient COPD patients was 2.5%, OSAS prevalence in hospitalized COPD patients was 6.7%, and that of OSAS patients was 11.2%. Patients with overlap syndrome and OSAS alone had significant differences in mean nocturnal oxygen saturation, apnea index, and hypoventilation index (P <0.01). Conclusions There is no necessary relationship between COPD and OSAS. The patterns of nocturnal respiratory disturbances in patients with overlapping syndrome are mainly alveolar hypoventilation and alveolar hypoventilation rather than apnea. The prevalence of hypoxia in patients with overlapping syndrome is more severe than that in patients with OSAS alone .