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目的观察复方甘草酸苷联合阿德福韦酯治疗慢性乙型肝炎的疗效。方法将60例患者随机分为两组,治疗组32例,给予阿德福韦酯10mg/次1次/d,且联合口服复方甘草酸苷片50mg/次3次/d;对照组28例,单服阿德福韦酯10mg/次1次/d。观察1年中肝功能恢复情况及HBV-DNA转阴率。结果治疗组肝功能恢复情况表明,HBV-DNA转阴率显著高于对照组(P<0.05)。结论复方甘草酸苷联合阿德福韦酯治疗慢性乙型肝炎疗效显著。
Objective To observe the curative effect of compound glycyrrhizin combined with adefovir dipivoxil on chronic hepatitis B patients. Methods Sixty patients were randomly divided into two groups: treatment group (32 cases), adefovir dipivoxil 10 mg / time (once / d), and compound oral glycyrrhizin tablets 50 mg / time 3 times / d, control group 28 cases , Single-serving adefovir dipivoxil 10mg / time 1 / d. Observe the recovery of liver function and the negative rate of HBV-DNA in one year. Results The recovery of liver function in the treatment group showed that the negative rate of HBV-DNA was significantly higher than that of the control group (P <0.05). Conclusion Compound glycyrrhizin combined with adefovir dipivoxil treatment of chronic hepatitis B has a significant effect.