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目的观察脑钠肽(BNP)在心房颤动(房颤)患者导管消融前后的变化,探讨其在预测房颤复发中的价值。方法经导管消融的房颤患者40例作为实验组,窦性心律患者40例作为对照组,收集实验组术前、术后,对照组入院第2天的血清,采用酶联免疫法测定血清脑钠肽(BNP)浓度。结果房颤组血清BNP浓度显著高于窦性心律组,经过导管消融后血清BNP浓度显著下降,差异有统计学意义。房颤患者导管消融成功组与窦性心律组BNP浓度比较差异无统计学意义,但复发组BNP浓度显著高于对照组,差异有统计学意义。结论BNP可能是预测房颤复发的一个有用指标,可反映心功能状态,BNP越高心功能越差,心功能低的患者房颤复发可能性大,但需要增加样本量进一步研究证实。
Objective To observe the changes of brain natriuretic peptide (BNP) before and after catheter ablation in patients with atrial fibrillation (AF), and to explore its value in predicting the recurrence of atrial fibrillation. Methods Forty patients with atrial fibrillation who underwent catheter ablation were selected as experimental group and 40 patients with sinus rhythm as control group.The serum of experimental group was collected before operation, Natriuretic peptide (BNP) concentration. Results The serum BNP level in AF group was significantly higher than that in sinus rhythm group. The serum BNP level decreased significantly after catheter ablation, the difference was statistically significant. There was no significant difference in the concentration of BNP between the successful group and the sinus rhythm group in patients with atrial fibrillation, but the BNP concentration in the recurrence group was significantly higher than that in the control group, the difference was statistically significant. Conclusions BNP may be a useful indicator to predict the recurrence of atrial fibrillation. It may reflect the state of cardiac function. The higher the BNP, the worse the cardiac function, and the lower the cardiac function is. However, it is necessary to increase the sample size for further study.