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[目的 ]探讨吸烟、血清淀粉蛋白A(SAA)与冠心病的关系。 [方法 ]采用ELISA法分别检测血浆中SAA、C 反应蛋白 (CRP)、白介素 6(IL 6)浓度。 [结果 ]血浆SAA、CRP浓度在对照组、心绞痛组和心梗组依次升高 ,SAA的浓度分别 2 .97,3 .90和 8.77mg/L ,CRP浓度分别为 3 .0 3 ,3 .10和 6.85mg/L ,两两比较差异有显著性 (P <0 .0 5 ) ;SAA与CRP的偏相关系数为 0 .793 ,呈正相关 (P <0 .0 5 ) ;SAA及CRP与IL 6间具较弱的正相关 ,r分别为 0 .15 7和 0 .3 14 ,均为P <0 0 5 ;吸烟与SAA在冠心病发生中具有交互作用。 [结论 ]高水平血浆SAA可能是冠心病的一个危险因素 ;吸烟与SAA在冠心病发生中具有交互作用 ,吸烟能增加高水平SAA患冠心病的危险性
[Objective] To investigate the relationship between smoking, serum amylin A (SAA) and coronary heart disease. [Method] The concentrations of SAA, C-reactive protein (CRP) and interleukin 6 (IL 6) in plasma were detected by ELISA. [Results] The levels of plasma SAA and CRP in the control group, angina pectoris group and myocardial infarction group were successively increased. The concentrations of SAA were 2.97, 3.90 and 8.77 mg / L, respectively, and the CRP concentrations were 3.30, 3, respectively. 10 and 6.85mg / L respectively, there was a significant difference between every two groups (P <0.05); partial correlation coefficient of SAA and CRP was 0.793 (P <0.05); SAA and CRP IL 6 had a weak positive correlation with r = 0.15 7 and 0.34, both P <0 05; smoking and SAA had an interaction in the development of coronary heart disease. [Conclusion] High level plasma SAA may be a risk factor of coronary heart disease. Smoking and SAA have interaction in the development of coronary heart disease. Smoking can increase the risk of coronary heart disease in high level of SAA