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目的:探讨中药内服联合灌肠对结直肠癌患者化疗后毒性、免疫功能及生存质量的影响,为临床治疗提供参考。方法:将80例结直肠癌患者随机分为对照组与治疗组各40例,对照组患者实施化疗,治疗组在化疗基础上联合中药内服及保留灌肠,对比两组患者化疗毒性反应发生率、免疫功能指标以及SF-36生存质量结果。结果:治疗组感染、溃疡、呕吐Ⅱ~Ⅳ级发生率分别为5.00%、0%、10.00%,均明显低于对照组,差异均有统计学意义(P<0.05);治疗组患者治疗后CD4+、CD8+、CD4+/CD8+与对照组比较,差异有统计学意义(P<0.05);治疗组与对照组SF-36生存质量指标治疗后比较,差异有统计学意义(P<0.05)。结论:中药内服联合灌肠能够有效改善结直肠癌患者化疗后毒性、免疫功能及生存质量。
Objective: To investigate the effect of oral administration of traditional Chinese medicine combined enema on the toxicity, immune function and quality of life of patients with colorectal cancer after chemotherapy, so as to provide reference for clinical treatment. Methods: 80 patients with colorectal cancer were randomly divided into control group and treatment group, 40 cases in each group. Patients in the control group were treated with chemotherapy. The treatment group was treated with traditional Chinese medicine and retention enema on the basis of chemotherapy. The incidence of chemotherapy toxicity was compared between the two groups. Immune function and SF-36 quality of life results. Results: The incidence of grade Ⅱ ~ Ⅳ infection, ulcer and vomit were 5.00%, 0% and 10.00% respectively in the treatment group, which were significantly lower than those in the control group (P <0.05). After treatment, There was significant difference between the control group and the control group (P <0.05). There was significant difference in the quality of life of SF-36 between the treatment group and the control group after treatment (P <0.05). Conclusion: Chinese medicine orally combined with enema can effectively improve the colorectal cancer patients after chemotherapy toxicity, immune function and quality of life.