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前言硝喹,Nitroquine,代号CI-679,简称679。化学全名2,4-二氨基-6-[(3′,4′-二氯苄基)-N-亚硝基-氨基]喹唑啉醋酸盐。化学结构如下: 国外研究了抗疟作用、药理、毒性等,但一直停留在实验研究阶段。我国1971年开始实验研究,1973年进入临床验证和现场防治观察。1979年10月鉴定。1980年批准小量试产。复方硝喹片每片含硝喹、氨苯砜各12.5mg,现将有关资料整理介绍: 四十年代抗疟药物研究中以其他含氮杂环代替喹啉环和嘧啶环,从而对喹唑啉类发生兴趣。1946年
Preface Nitroquine, Nitroquine, code CI-679, referred to as 679. Chemical name 2,4-diamino-6 - [(3 ’, 4’-dichlorobenzyl) -N-nitroso-amino] quinazoline acetate. The chemical structure is as follows: Foreign studies on anti-malarial effects, pharmacology, toxicity, etc., but has stayed in the experimental research stage. Our country began experimental research in 1971, entered the clinical verification in 1973 and on-site prevention and treatment observation. October 1979 identification. Approved a small amount of pilot production in 1980. Each compound contains nitrate quinoa, dapsone each 12.5mg, now the relevant information to organize the introduction: the anti-malarial drugs in the forties research to replace other nitrogen-containing heterocyclic ring quinoline and pyrimidine ring, thus quinazole Amines interested. 1946