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Benichou等(1992年)认为,罗红霉素(roxithromycin)比红霉素衍生物有较好的肝耐受性,可能与其受肝细胞色素P_(450)代谢程度轻及每日用量少有关。但本文报道1例年轻妇女,用罗红霉素治疗,引起了暴发性急性肝炎。患者,女,23岁,患黄疸入院。9月16日,因疑有无症状性生殖器衣原体属感染而始用罗红霉素150mg,2次/d治疗。4天后,患者出现头痛和感冒样症状。治疗第5天,发生呕
Benichou et al. (1992) argue that roxithromycin has better liver tolerance than erythromycin derivatives and may be related to its light metabolism and less daily dose of hepatocyte pigment P 450 . However, 1 case of young women is reported in this paper, treated with roxithromycin, causing fulminant acute hepatitis. Patient, female, 23 years old, suffering from jaundice admitted to hospital. September 16, due to suspected asymptomatic genital Chlamydia genus infection with roxithromycin 150mg, 2 times / d treatment. Four days later, the patient developed headache and flu-like symptoms. On the fifth day of treatment, vomiting occurred