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研究结果表明,硅取代的化合物具有较高的化学反应性和亲脂性,易透过脂质层,生物利用度较高,毒性比较低,为寻找高效、低毒药物的研究提供了一个新的方向。硅取代生物活性化合物的研究大体上分为三种类型:用有机硅作为取代基对已知药物的羟基或胺基进行修饰,生成相应的 Si-O、Si-N 键,成为前体药物。用硅原子置换已知药物中的碳原子,得到相应的含硅化合物。合成全新结构的有机硅化合物,并进行生物试验。
The results show that the silicon-substituted compounds have high chemical reactivity and lipophilicity, easy to penetrate the lipid layer, high bioavailability and low toxicity, providing a new direction for the search for highly effective and low toxicity drugs . There are three types of studies on the substitution of bioactive compounds with silicon: silicones are used as substituents to modify the hydroxyl or amine groups of known drugs to form the corresponding Si-O and Si-N bonds and become prodrugs. Replacement of carbon atoms in known drugs with silicon atoms gives the corresponding silicon-containing compounds. Synthesis of a new structure of organic silicon compounds, and biological tests.