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评价12例儿童期患白血病或恶性淋巴瘤接受过全身照射(TBI)和骨髓移植(BMT)的女性患者的子宫、卵巢容积及子宫血流的测定结果,并与相同年龄的正常女性对照。其中位年龄确诊时11.2(2.5～15.0岁)岁,BMT时12.7(6.1～17.6)岁,随访时21.5(11.6～25.6)岁。BMT至随访间隔时间8.2(4.0～10.9)年。BMT前全部患者接受了多种药物联合化疗,4/12接受了颅脑照射(CI),无1例接受脊髓照射。BMT时3例第一次完全缓解期(CR_1),9例CR_2。BMT预处理方案为环磷酰胺60mg/kg.d连用2天,TBI采用两种方法:4例中线剂量8.5～10Gy(6cGy/min)一次照射;8例总中线剂量10.9～11.7Gy,分三次照射,间歇24小时(6～8.8cGy/min)。用ALOKA SSD680加
The results of determination of uterine, ovarian volume and uterine blood flow in 12 children with childhood leukemia or malignant lymphoma who underwent total body irradiation (TBI) and bone marrow transplantation (BMT) were evaluated and compared to normal women of the same age. The median age was 11.2 (2.5 to 15.0 years) at diagnosis, 12.7 (6.1-17.6) at BMT, and 21.5 (11.6-25.6) years at follow-up. BMT to follow-up interval of 8.2 (4.0 ~ 10.9) years. All patients underwent BMT before chemotherapy, 4/12 received intracranial irradiation (CI), and none received spinal cord irradiation. The first complete remission (CR_1) was in 3 cases and the CR_2 in 9 cases in BMT. BMT pretreatment regimen was cyclophosphamide at 60 mg / kg.d for 2 days, and TBI was performed in two ways: 4 with a midline dose of 8.5 to 10 Gy (6 cGy / min) and 8 with a median midline dose of 10.9 to 11.7 Gy in three Irradiation, intermittent 24 hours (6 ~ 8.8cGy / min). With ALOKA SSD680 plus