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【目的】研究手足口病流行规律,为改进防治措施提供依据。【方法】通过分析2009年山东省聊城市手足口病(hand foot mouth disease,HFMD)16 749例的流行规律、病原学检测、影响预后的因素,总结降低病死率的方法。【结果】小于4岁儿童发病率高、病死率高。极重症发病率和病死率与性别无关。咽拭子和/或肛拭子RT-PCR法检出EV71为54.6%,二者同时检查可提高阳性率。【结论】正确掌握HFMD流行规律、采取分级管理和治疗、及早发现极重症患儿、采取正确治疗措施可显著降低病死率。
【Objective】 To study the epidemic rule of hand-foot-mouth disease and provide basis for improving prevention and cure measures. 【Methods】 The prevalence of 16 749 hand foot mouth disease (HFMD) patients in 2009 in Liaocheng City of Shandong Province was analyzed. The etiological factors and prognostic factors were analyzed, and the methods of reducing mortality were summarized. 【Results】 Children less than 4 years old had high incidence and high mortality rate. Very severe morbidity and mortality have nothing to do with gender. The EV71 was 54.6% detected by RT-PCR with throat swabs and / or anal swabs. The simultaneous detection of both could increase the positive rate. 【Conclusion】 Correct understanding of the epidemic of HFMD, management and treatment by grading, early detection of critically ill children, to take the correct treatment can significantly reduce mortality.