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目的探讨脉血康联合阿司匹林治疗急性缺血性脑卒中的疗效。方法 96例急性缺血性脑卒中患者,随机分为脉血康组(31例)、双抗组(33例)和对照组(32例)。脉血康组使用脉血康胶囊联合阿司匹林治疗,双抗组使用氯吡格雷联合阿司匹林治疗,对照组单用阿司匹林治疗,比较三组治疗效果。结果三组患者在入院时及治疗后7 d时的美国国立卫生研究院卒中量表(NIHSS)评分比较差异无统计学意义(P>0.05)。治疗后14、90 d时,脉血康组和双抗组NIHSS评分优于对照组(P<0.05),但脉血康组与双抗组NIHSS评分比较差异无统计学意义(P>0.05)。三组治疗后7 d时的NIHSS评分与入院时比较差异均无统计学意义(P>0.05);而治疗后14、90 d时的NIHSS评分均低于入院时,差异具有统计学意义(P<0.05)。三组7 d内NIHSS评分增加≥2分患者数量均为5例,三组间两两比较差异均无统计学意义(P>0.05)。所有患者中出现2例药物引起的消化道出血,均发生在双抗组,经停药治疗后好转。结论脉血康联合阿司匹林治疗急性缺血性脑卒中的疗效与氯吡格雷联合阿司匹林疗效相似,优于单用阿司匹林患者。
Objective To explore the curative effect of pulse XueKang combined with aspirin in the treatment of acute ischemic stroke. Methods A total of 96 patients with acute ischemic stroke were randomly divided into two groups, ie, Xuexuekang group (31 cases), double-antibody group (33 cases) and control group (32 cases). The pulse Xuekang group was treated with “Maishenkang capsule combined with aspirin”, the double-antibody group was treated with clopidogrel combined with aspirin, the control group was treated with aspirin alone, and the effect of the three groups was compared. Results There was no significant difference in the NIHSS score between the three groups on admission and on the 7th day after treatment (P> 0.05). At 14 and 90 days after treatment, the NIHSS score of Minaoxu group and double-antibody group was better than that of the control group (P <0.05), but there was no significant difference between the NIHSS score of the two groups (P> 0.05) . There was no significant difference in NIHSS score between the 7th day and the 3rd day after treatment (P> 0.05). NIHSS scores at 14 and 90 days after treatment were lower than those at admission (P> 0.05) <0.05). The number of patients with NIHSS score≥2 in three groups on day 7 was 5 cases. There was no significant difference between any two groups (P> 0.05). All patients had 2 cases of gastrointestinal bleeding caused by drugs, both in the double anti-group, after stopping treatment improved. Conclusion The clinical efficacy of pulse Xuekang combined with aspirin in the treatment of acute ischemic stroke is similar to that of clopidogrel combined with aspirin, which is superior to that of aspirin alone.