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早在本世纪50年代末至60年代初，长春花碱（VLB）和长春新碱（VCR）相继问世以来，两者均已作为常用抗肿瘤植物药被广泛用于临床，两者分别以对霍奇金和急性白血病的显著疗效而被医学同道所公认，但是因存在一些与剂量有关的毒副作用而有时使两者的使用受到限制。国外于70年代
As early as the late 1950s and early 1960s, both vinblastine (VLB) and vincristine (VCR) have been widely used clinically as commonly used anti-tumor botanicals, Hodgkin’s and acute leukemia have been recognized by medical experts for their significant efficacy, but their use is sometimes limited by the presence of some dose-related side effects. Abroad in the 70’s